BMT Funded Research

Recently Funded Research

Understanding Why and How Canine Osteosarcoma Tumors Spread – funded research
2016 Funded Research
Development of Anti-IgE Peptide for Treatment of Canine Allergy–Updated
Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma– Updated
Probiotic VSL# 3 Reduces Enteritis in Dogs with Inflammatory Bowel Disease
c-Kit Mutation and Localization Status as Response Predictors in Canine Mast Cell Tumors Treated with Toceranib or Vinblastine: A Response-Adaptive Randomized Trial
AKC CHF Bloat Initiative–Charter Sponsor

The Briard Medical Trust (BMT) has been working closely with the four major cancer researchers and labs in the country. They are: Dr. Elaine Ostrander at National Institutes of Health (NIH), Ostrander’s Canine Genomics Lab at the National Human Genome Research Institute; Dr. Kerstin Lindblad-Toh at the The Broad Institute at Harvard and MIT; Dr Jaime Modiano at the University of Colorado, AMC Cancer Research Center; and, Dr. Matthew Breen at North Carolina State University, Canine Genomics Lab. Each of these prominent researchers are experts in different aspects of cancer research and are funded, in part, by the Canine Health Foundation (CHF). While the work of these researchers are both complimentary and collaborative, each project has specific research protocols (clearly defined rules of how the science will be conducted). Some of the studies require only the DNA from blood, some require only fresh tumor tissue, some require blood and tissue which has been preserved.

Since the processing of blood and tissue is costly and research funding is limited, the researchers have asked that our sample submissions be limited to their current needs. Before all else, we were to provide blood samples of Briards to be used as controls (comparison) for dogs affected with various diseases. The criteria included older dogs, free of certain diseases, who were not related to other dogs in this group at the parent or grandparent level. As you can see, this criteria by design, mandates genetic diversity.

Dr. Modiano asked for blood from 10 Briards, over the age of 10, who had not had lymphoma and who were not related to each other for 3 generations. This blood was to be sent to NIH. Once we had organized the initial 10 samples, we were asked for another 10. This blood will be used for lymphoma studies by Drs. Modiano, Breen, and Ostrander. Each researcher has their area for this research. Dr. Modiano is looking at what turns the cancer cells on and what cells could turn them off. Dr. Breen is looking at the chromosome aberrations. Dr. Ostrander is working on haplotype mapping. To date, this has been part of large, on-going lymphoma studies to which the BCA and ASBC have contributed.

Dr. Ostrander then recruited dogs from the group mentioned above to participate in her “Genetics of Breed Morphology” study. The morphology study is looking to discover genes for the skeletal size and shape in all dog breeds; genes that determine the shape of the skull and length of the limbs in all dog breeds; the genetic basis of hip dysplasia; and the genetic basis of achrondroplasia (dwarfed limbs) in certain breeds.

Dr. Lindblad-Toh has requested that we set up a control group for her research. The criteria for these studies include 20 dogs, 8 years and older, who have not had hemangiosarcoma, osteosarcoma, mast cell or mammary tumors, melanoma or B cell lymphoma. Again, they cannot be related at the parent or grandparent level. She also needs the blood of Briards affected by any of these diseases, whatever the age, drawn prior to chemotherapy or in remission after chemo. The other researchers cannot use blood or tissue from dogs who have had chemo. As we submit samples of the affected dogs, we also recruit samples from first degree relatives to be used for comparison. Dr. Lindblad-Toh is working on gene mapping.

In addition to working with Dr. Modiano on the lymphoma study reported in the last Dew Claw (the BCA official publication), Dr. Breen is now working with the blood and tissue of three Briards diagnosed with fibrosarcoma and one with hemangiopericytoma. If your dog is diagnosed with a fibrosarcoma or hemangiopericytoma, he would be interested in both blood and tissue of dog, before the dog is treated. This is part of a study on soft sarcomas.